Unfortunately, medications to treat chronic intestinal pseudo-obstruction are limited. A variety of different medications may be used to treat individuals with CIP. Medications can help to control symptoms and to avoid complications. Antibiotics may be prescribed to treat bacterial infections and can help relieve diarrhea and bloating. Drugs that are effective against nausea and vomiting (antiemetics) may also be used.
Prokinetics are a class of drugs that are often prescribed to individuals with CIP in order to improve gastrointestinal motility. Examples of prokinetic drugs are Erythromycin, Metoclopramide (Reglan), Domperidone, Octreotide, Tegaserod, Lubiprostone and Prucalopride.
Low-dose tri-cyclic antidepressants and gabapentin have been used to treat chronic pain and to help with nausea.
Pain medications such as narcotics should be avoided because they can further deteriorate digestive function by decreasing motility.
Antiemetics are used to treat nausea and vomiting. Examples include Promethazine (Phenergan), Prochlorperazine (Compazine), Ativan, and Ondansetron (Zofran)
Ativan – used to control nausea, but causes extreme drowsiness
Bethanechol – Used to stimulate esophageal motility
Marinol– Approved Marijuana drug that is given to chemo patients or others with severe nausea
PPI– Used for GERD as well as healing esophagus due to acid. Examples: Prevacid, Prilosec, Nexium, Protonix, Aciphex
Periactin (cyproheptadine)- Used to relax pyloric sphincter and as appetite stimulant
Be sure to discuss your medication plan with your physician, especially what side effects to expect. What works for one patient may not work for another, and it may take some trial and error to find the right combination that works for you.